Remarkable sex-specific transcriptional solutions is recapitulated in the mice immediately following CVS
We next assessed whether similarly dramatic sex differences in transcriptional profiles are produced in mice in response to CVS. We found that 21 days of CVS induced a range of depression- and anxiety-related behavioral abnormalities to an equivalent degree in male vs. female mice ( Figure 2a–d ). These include increased latency to eat in the novelty-suppressed feeding test (F(step 1,40)=24.3, p (1,40)=8.68, p (1,40)=3.61, p=0.06; Figure 2c ) and decreased sucrose preference (F(1,40)=, p
I made use of RNAseq in order to survey new transcriptome in two representative mind places, vmPFC and you will NAc, out of 20 guys and you may 20 people (half troubled, half unstressed control).
