Even though the shortage of Blk mRNA and you may protein term from inside the mouse thymocytes will not service these investigation (Fig
The brand new exclusive term out of Blk during the B tissues might have been challenged because of the breakdown of Blk phrase inside human thymocytes (10). ? (Fig.1C), 1 C), a prospective aftereffect of Blk lack for the T-cell invention is actually investigated. The newest thymuses from Blk-lacking and you may manage mice was basically of equal dimensions, in addition to ratios regarding CD4 and you may CD8 cells about thymuses and you can spleens off Blk-deficient rats had been just like inside the 129/Sv manage rats (data not shown). I plus don’t place one difference in T-mobile receptor ??, CD3?, heat-secure antigen, and you will CD69 term during the splenic T-telephone and you will thymocyte subpopulations out-of control and Blk-lacking rats (data not shown).
Necessary protein tyrosine phosphorylation.The new [...]
